Inhibition of bacteria and white-rot-fungi by newly synthesized furfural derivatives

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Jian-Lan Wang, Wen Gu, Shi-Fa Wang


New N-alkylfurfurylacetamides were synthesized and characterized from abundant biomass derived furfural by a simple and straightforward procedure with overall yields of 51 to 92%. The antimicrobial activity of the synthesized compounds were then investigated and it was found that N-benzyl-N-furfurylacetamide and N-cyclohexyl-N-furfurylacetamide showed promising activity against bacteria, particularly white-rot-fungi, suggesting a feasible new type of anti-fungal agent in applications to protection and conservation of cultural heritage.


furfural, N-alkyl furfurylamines, N-alkyl-N-furfurylacetamide, antibiotic activity, white-rot-fungi

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